Search results for " high resolution"
Article
Tips for High Resolution Ion Exchange Chromatography to Obtain a Pure Protein
A high-resolution ion exchange chromatography run is key for obtaining high protein purity. The better the separation between peaks, the higher the purity of the proteins that will be collected.
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Article
Process Chromatography: Continuous Optimization
“Next-generation IEX resins that offer high capacity, high resolution, and salt tolerance at faster flow rates have significantly improved process flexibility and allow for easy adaptation to integrat…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
By Marcos Simon, Juan J. Giner-Casares
Cell…
Article
Evolution of the Monoclonal Antibody Purification Platform
The authors discuss the evolution of the purification platform for manufacturing of mAb therapeutics.
Monoclonal antibodies (mAb) increasingly form the majority share of the product pipeline…
Article
Virus-like Particles as Therapeutic Moieties of the Future
Such high resolution allows analysis of even small shifts in particle size and hence can be used to analyze size distribution in a VLP preparation (21). Physical parameters of VLPs such as molecular m…
Article
A Closer Look at Affinity Ligands
Affinity ligands play an exciting role in the ever-growing sphere of downstream processing. In speaking with BioPharm International®, Phillip Elliott, PhD, associate director of Process Development,…
Article
The Challenge of Disruptive Technologies in Bioprocessing
Next-generation ion exchange chromatography resins like POROS XS (strong cation exchange) and XQ (strong anion exchange) offer high capacity, high resolution, and salt tolerance at faster flow rates f…
Article
Using Quality by Design to Develop Robust Chromatographic Methods
Quality-by-design principles can be used to understand chromatographic measurement system variability.
Sep 2, 2014
By: Melissa Hanna-Brown, Kimber Barnett, Brent Harrington, Tim Graul, Jim…
Article
Tackling Analytical Method Development for ADCs
“There is also increasing interest in the use of high resolution accurate mass spectrometry to support various facets of ADC bioanalysis given the complex and dynamic nature of these molecules,” says …
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
If used correctly, these new analytical methods can reduce analysis and product development time.
ABSTRACT
Monoclonal antibodies represent a significant portion of sales in the biopharma…